Nyeri is served by a reasonably well-maintained tarmac road network connecting it to Nairobi, Nakuru, Nanyuki, Othaya and other surrounding towns.

Most transportation of cargo to and from Nyeri is by road, though the town has a largely underutilized railway station at Kiganjo (about 10 kilometers out of town towards Nanyuki) on the branchline of the railway from Nairobi to Nanyuki, and an Airstrip at Mweiga (about 15 Kilometers out of Town towards Nakuru). The main mode of public passenger transport to, from, and within Nyeri is by way of fourteen-seater minibus taxis (matatus), though un-metered (but inexpensive) saloon car taxis are also widely used within the town.